ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Serum Levels Of Nitric Oxide And Malondialdehyde In Patients With Brucellosis
Dr. Lütfü SAVAŞ,a Dr. Yusuf ÖNLEN, a Dr. Nazan SAVAŞ,b Dr. Gürbüz POLAT, c Dr. Gönül ASLANd
aEnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji AD, bMediko-Sosyal Ünitesi Halk Sağlığı AD, Mustafa Kemal Üniversitesi Tıp Fakültesi, HATAY
cBiyokimya AD, dTıbbi Mikrobiyoloji AD, Mersin Üniversitesi Tıp Fakültesi, MERSİN
Objective: The aim of this study was to determine serum levels of nitric oxide (NO) and malondialdehyde (MDA) in patients with brucellosis and to compare these levels with laboratory tests such as erythrocyte sedimentation rate (ESR), aspartate aminotransferase (AST), alanine aminotransterase (ALT), brucella serum agglutination test (SAT), as well as clinical findings such as fever, sweating, and arthricular pain for the diagnosis of brucellosis.
Material and Methods: In this study, serum NO and MDA levels were determined in 39 patients with brucellosis before treatment, and in 20 healthy individuals as a control group. Nitrate levels were measured by Green’s method, and Yagi’s method was used to determine MDA levels.
Results: Serum NO and MDA levels were significantly raised in patients with brucellosis when compared to those of the control group (p< 0.05). There was no relation between serum levels of NO, SAT, AST, ALT, or fever, sweat, and arthricular pain. Contrarily, the ESR was also high in patients with high levels of NO (p< 0.05). In addition, there was no relation between MDA and ESR, ALT, SAT, fever, and arthricular pain (p> 0.05); however, in patients with AST levels higher than 40 IU/L, levels of MDA were low (p< 0.05). Furthermore, MDA levels were high in patients with a history of sweating (p< 0.05).
Conclusion: Further studies are needed in order to determine whether high levels of NO and MDA in patients with brucellosis are clinically significant.Keywords: Brucellosis, malondialdehydeTurkiye Klinikleri J Med Sci 2005, 25:478-482
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