ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
An Investigation Of The Effects Of Diet And Simvastatin Treatment On Serum Lipid Profile And Hdl Sub-fractions
Dr. Nihal MALAY,a Dr. Şenay KESER,a Dr. Elmas ÖĞÜŞ,a
Dr. Nermin ÇELEBİ,a Dr. Beril AKMAN,b Dr. Doğan YÜCELa
aBiyokimya ve Klinik Biyokimya Laboratuvarı, bDahiliye Kliniği S.B. Ankara Eğitim ve Araştırma Hastanesi, ANKARA
Objective: In this study involving patients with cholesterol/high density lipoprotein (HDL) cholesterol ratios > 5.6, which is an atherogenic risk index for coronary artery disease (CAD), the effects of diet and simvastatin treatment on serum lipid profile and HDL cholesterol sub-fractions were investigated.
Material and Methods: Total cholesterol, triglyceride, low-density lipoprotein (LDL-C), very low-density lipoprotein (VLDL-C), high-density lipoprotein (HDL-C), HDL2-C, HDL3-C and cholesterol/HDL ratios were evaluated in 40 patients with cholesterol/HDL cholesterol ratios > 5.6.
Results: After diet and diet + simvastatin therapy, total cholesterol levels were decreased by 1% (p> 0.05) and LDL-C levels were increased by 4% (p> 0.05) in the diet group, whereas both total cholesterol and LDL-C levels were significantly decreased in the diet + simvastatin group, 5% and 20%, respectively (p< 0.05 and p< 0.05). In the diet group, HDL-C and HDL3-C levels were increased by 5% and 23%, respectively (p>0.05 and p= 0.002), and HDL2-C levels were decreased by 11% (p= 0.019). In the diet + simvastatin group, significant increases in HDL-C (11%; p= 0.0002), HDL2-C (40%; p= 0.0003) and HDL3-C (5%; p= 0.036) were determined.
Conclusion: The therapeutic approach (i.e. diet + simvastatin) appears to be more effective than dietary treatment alone for the prevention of atherogenesis and regression of hyperlipidemia.Keywords: Hyperlipidemia, diet, simvastatin, lipoproteins, HDL cholesterolTurkiye Klinikleri J Med Sci 2005, 25:471-477
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