ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Salivary Nitric Oxide Levels In Sjogren’s Syndrome
Zuhal PARILDAR*, Tufan TÜRK**, Dilek ÖZMEN***, Gökhan KESER****,
Yasemin KABASAKAL*****, Oya BAYINDIR***
* Uz.Dr., Ege Üniversitesi Tıp Fakültesi Biyokimya AD, Klinik Biyokimya BD, İZMİR
** Uz.Dr., Pamukkale Üniversitesi Tıp Fakültesi Romatoloji BD, DENİZLİ
*** Prof.Dr., Ege Üniversitesi Tıp Fakültesi Biyokimya AD, Klinik Biyokimya BD,
**** Doç.Dr., Ege Üniversitesi Tıp Fakültesi İç Hastalıkları AD, Romatoloji BD,
*****Prof.Dr., Ege Üniversitesi Tıp Fakültesi İç Hastalıkları AD, Romatoloji BD, İZMİR
Background: Nitric oxide (NO) has been shown to be in-volved in mechanisms mediating nerve-evoked vasodila-tory and secretory responses in salivary glands. In the present study, the stabil nitric oxide metabolites nitrite and nitrate levels were measured in primary Sjögren’s syndrome (pSS) patients’ saliva.
Methods: Fifty patients with pSS fulfilling EC criteria for pSS (47.3 ± 9.48 years old, mean ± SD), and 32 healthy con-trols (35 ± 8.2 years old) were enrolled to the study. Sali-vary nitrite was measured by the Griess reaction and nitrate by the enzymatic method of Bories and Bories.
Results: Two or four joint involvement was observed in 23 of patients. 60% of the patients have shown ANA, 50% RF, 42% anti-La and 54% anti-Ro autoantibody positivity. Salivary NO (nitrite+nitrate) levels were significantly higher in pSS patients when compared to the controls (392.9 ± 94.97 and 162.72 ± 85.69 mmol/L, respectively, p=0.0001). There were not significant differences in NO levels between patients with and without arthiritis and ANA, anti-La, anti-Ro and RF pozitive and negative pa-tients, one by one.
Conclusion: pSS patients had significantly increased salivary NO concentrations. Although the mechanism of actions of NO remains to be identified, it has been suggested that it may involve inhibition of some secretory mechanisms. Increased NO may contribute to the pathophysiology of xerostomia in pSS.Keywords: Sjogren syndrome, Saliva, Nitric oxideTurkiye Klinikleri J Med Sci 2003, 23:295-299
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