ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Comparison Of The Effects Of Remifentanil And Fentanyl On Thehemodynamic Response To Tracheal Intubation
Şaziye ÖZCAN*, Hülya BAŞAR*, Özlem ANBARCI**, Alpaslan APAN*, Ünase BÜYÜKKOÇAK*,
Osman ÇAĞLAYAN***
* Yrd.Doç.Dr., Kırıkkale Üniversitesi Tıp Fakültesi Anesteziyoloji ve Reanimasyon AD,
** Arş.Gör.Dr., Kırıkkale Üniversitesi Tıp Fakültesi Anesteziyoloji ve Reanimasyon AD,
***Doç.Dr., Kırıkkale Üniversitesi Tıp Fakültesi Biyokimya AD, KIRIKKALE
Purpose: It is well known that laryngoscopy and intubation provide hemodynamic changes by stimulating sympathoadrenergic response. The aim of this study was to compare the effects of fentanyl and remifentanil on stress response to tracheal intubation during induction. Materials and Methods: Forty ASA (American Society of Anesthesiologists) class I and II patients undergoing surgery electively were included to the study. Induction of anesthesia was performed with thiopental sodium 4-5 mg/kg and vecuronium bromide 0.1 mg/kg, intravenously. Maintenance of anesthesia was achieved with sevoflurane 2% in N2O/O2 mixture at 50%. Patients were randomly assigned to one of two groups (n=20) and received remifentanil or fentanyl (1 μg/kg) during induction. Heart rate and mean arterial pressure measurements were recorded before and 2 minutes after induction, and 1 and 5 minutes after intubation. Plasma glucose, cortisol, prolactin and growth hormon levels were determined at the same periods.Results: There were more significant increase in heart rate and mean arterial pressure,1 and 5 minutes after intubation in fentanyl group, when comparing with remifentanil group. Altough the increase of plasma cortisol and prolactin levels were determined 1 minute after intubation in remifentanyl group, the levels remained lower than fentanyl group.Conclusion: We thought that remifentanil was more effective than fentanyl for attenuating hemodynamic response to laryngoscopy and intubationKeywords: Laryngoscopy, Hemodynamic Processes, Intubation, Intratracheal, remifentanil, FentanylTurkiye Klinikleri J Med Sci 2003, 23:204-207
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