ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Evaluation Of Late Radiation Toxicity In Patients With Headand Neck Cancer
Zeynep ÖZSARAN*, Deniz YALMAN*, Gökçen YILDIRIM**, Morteza PARVIZI**,
Mustafa ESASSOLAK***, Ayfer HAYDAROĞLU****
* Yrd.Doç.Dr.,Ege Üniversitesi Radyasyon Onkolojisi AD,
** Asis.Dr., Ege Üniversitesi Radyasyon Onkolojisi AD,
*** Doç.Dr., Ege Üniversitesi Radyasyon Onkolojisi AD,
**** Prof.Dr., Ege Üniversitesi Radyasyon Onkolojisi AD, Bornova-İZMİR
Purpose: In order to evaluate the late radiation toxicity and the prognostic factors influencing the development of late toxicity 120 patients who received radiotherapy to head and neck region were evaluated according to RTOG/EORTC (Radiation Therapy Oncology Group/ European Organization for Research and Treatment of Cancer) scoring criteria.Patients and Methods: Tumor localization was as follows: larynx 53 patients (44.2%), nasopharynx 17 patients (14.2%), tongue 13 patients (10.8%), floor of the mouth, buccal mucosa 7 patients (5.8%), hypopharynx, tonsil and parotis 10 patients (8.3%), unknown primary with cervical lymph node metastases 20 patients (16.7%). Median irradiation dose was 66 Gy (range:54-90). In 103 patients Co 60 teleterapy machine and in 17 patients 6-25 MV lineer accelarator was used.Results: No late radiation toxicity was seen in 17 patients (14.2%). Thirty-nine patients (32.5%) had Grade I, 49 had (40.8%) Grade II and 15 had (12.5%) Grade III toxicity. Prognostic factors such as gender (p=0.799), prior operation (0.743), irradiation dose (<66 Gy)(p=0.229), beam energy (p=0.860), socioeconomic status (p=0.440), use of chemotherapy (p=0.656) had no significant effect on the development of toxicity, but the operation type (tumor excision alone or tumor excision with neck dissection) had significant impact (p=0.004). Also late toxicity was more frequent when more than 50% of oral mucosa was included in the treatment field (p=0.006).Conclusion: High rates of late radiation toxicity of various grades develop in patients with head and neck cancer. Side effects should be evaluated in each patient before, during or after radiotherapy using a standard grading system. Thus the patients susceptible to develop late effects could be predicted and with the necessary precautions quality of life could be improved.Keywords: Radiotherapy, Head and Neck NeoplasmsTurkiye Klinikleri J Med Sci 2003, 23:195-199
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