ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Lipid Peroxidation, Antioxidant Activityand Pulmonary Functon Test In Smokers
Filiz ÇİMEN* Bahar ULUBAŞ**, Türkan ERYILMAZ***, Gülden BİLGİN****
* Dr., Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Merkezi, Göğüs Hast Uzmanı, ANKARA
** Dr., Mersin Üniversitesi Tıp Fakültesi Göğüs Hastalıkları AD, Göğüs Hast Uzmanı, MERSİN
*** Dr., Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Merkezi, Biyokimya Uzmanı,
**** Dr., Ankara Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları Uzmanı, ANKARA
Smoking, causing an imbalance between oxidants and anti-oxidants, has been considered in the pathogenesis of several lung disease, such as chronic obstructive pulmonary disease.Purpose: To investigate, superoxide dismutase (SOD), malondial-dehyde (MDA) concentration in smoker and non-smoker, and relation between consumption amount of the cigarette and pulmonary function test (PFT). Material and Method: MDA and erythrocyte SOD levels, PFT (FEVı %, FEVı/FVC %, FEF25-75 %) and amount of cigarette consumption in the 20 healthy smokers were compared with in the 20 healthy non-smokers. Results: In smokers FEVı/FVC% and FEF25-75% were significantly lower than controls (p<0.03, p<0.01). Additionally in smokers group the MDA (13.673 ± 5.247 nmol/ml ) was found significantly higher , than that of the controls (10.042 ± 3.717 nmol/ml) (p< 0.001) and also, level of the MDA was found moderate relation amount of the cigarette consumption (r –0.40) and decrease of the FEVı/FVC %, FEF25-75 %. Controversially, SOD concentration were not statistically different from controls and were not found any relation between level of the SOD and amount of the cigarette con-sumption and PFTConclution; Our results have shown that cigarette smoking increases serum MDA levels, this increasing correlation with the consumption amount of the cigarette and decrease of the pulmonary function test parameters. Any relationship was not found between these parameters and the level of SOD. This results may be explained with SOD was not conducted as early mechanism to compose the oxidant/ antioxidant imbalance.Keywords: Antioxidants, Superoxide dismutase, Malondialdehyde, SmokingTurkiye Klinikleri J Med Sci 2002, 22:292-296
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