ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Interaction Between Serum Bilirubin Leveland Lipid Profile
Özlem YAVUZ*, Şükrü ARAS*
*Assoc.Prof., University of Abant İzzet Baysal, Faculty of Medicine, Department of Biochemistry and Clinical Biochemistry, DÜZCE
Lipid oxidation, a which is accepted as an important element of arterial plaque formation and atherosclerosis, is involved in the pathophysiology of cardiovascular diseases (CVD). Due to the fact that bilirubin has antioxidant properties, it has recently been suggested that increased physiological concentrations of serum bilirubin may have a protective role in the atherosclerotic process. In addition an inverse relationship between circulatory total bilirubin and increased risk of CVD has been reported. However, information on this topic remains scarce. The aim of this study was to evaluate the relationships between serum bilirubin and lipid profile in middle-aged 250 subjects (135 female). Serum bilirubin concentrations were measured with colorimetric method and divided into three groups : < 0,4, 0,47-0,53 and > 0,7 mg/dl. Lipid profile parameters which were studied include total cholesterol (TC) , triglycerides (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), apolipoprotein B (Apo B), apolipoprotein A-I (Apo A-I) and lipoprotein (a) [Lp (a)]. When calculated by Pearson correlation coefficients, there was no correlation between bilirubin and lipid profile in three groups. One-way ANOVA variance analysis was also indicated that there was no significant difference between lipid profiles in three groups.Consequently, it may be said that there is a relationship between bilirubin and CVD, compatible with previous studies, but we have not observed any relationship between bilirubin and lipid profile.Keywords: Bilirubin, Lipoproteins, Lipids, Cardiovascular DiseasesTurkiye Klinikleri J Med Sci 2002, 22:276-280
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