ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Relationship Of Cadmium Induced Hypoacidity With Parietalcell Morphology Of Stomach In Rats
Mevlüt ASAR*, Ümit Ali KAYIŞLI**, V. Nimet İZGÜT-UYSAL***, Gülsen ÖNER****, Mehmet KAYA*****
* Prof.Dr., Akdeniz Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji AD,** Arş.Gör., Akdeniz Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji AD,*** Doç.Dr., Akdeniz Üniversitesi, Tıp Fakültesi, Fizyoloji AD,**** Prof.Dr., Akdeniz Üniversitesi, Tıp Fakültesi, Fizyoloj AD, ANTALYA***** Prof.Dr., Çukurova Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji AD, ADANA
In this study, totally 56 adult male Swiss albino rats (average 190-200 g) were used. It was investigated at light and transmission electron microscopic levels whether the hypoacidity observed in rats fed for 30 days orally with normal food and 15 ppm cadmium (CdCl2) added drinking water is related with gastric parietal cell morphology. In our findings, blood and tissue cadmium levels of animals exposed to cadmium were increased, the values of their basal acid and mucin content were decreased. Parietal cell population was also decreased and their tubulovesicle membranes were torn.As a result, we think that the hypoacidity observed in rats exposed to cadmium, may depend on diminishing parietal cell population or back diffusion of luminal acid from the broken gastric mucosal barrier.Keywords: Rats, Stomach, Parietal Cells, CadmiumTurkiye Klinikleri J Med Sci 2002, 22:249-254
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