ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Histological Alterations Of Rat Testes In Experimental Diabetes
Feral ÖZTÜRK*, Mehmet GÜL**, Mustafa AĞKADİR***, Murat YAĞMURCA****
* Yrd.Doç.Dr., İnönü Üniversitesi Tıp Fakültesi Histoloji Embriyoloji AD,
** Arş.Gör., İnönü Üniversitesi Sağlık Bilimleri Enstitüsü,
*** Arş.Gör.Dr., İnönü Üniversitesi Tıp Fakültesi Farmakoloji AD,
****Arş.Gör.Dr., İnönü Üniversitesi Tıp Fakültesi Histoloji Embriyoloji AD, MALATYA
Purpose: The purpose of this study was to examine and evaluate the alterations in rat testes histology following streptozotocin (STZ)-induced and fructose-induced experimental diabetes.Material and methods: Fifteen male Sprague-Dawley adult rats were divided into three groups. One has been fed by normal rat diet and tap water (control group, n=5), second has been given one dose of 45mg/kg STZ intraperitoneally (i.p) and fed by normal rat diet (STZ group, n=5) and tap water, third has been fed by normal rat diet and tap water containing 10 % D-Fructose (fructose group, n=5) for 8 weeks. At the end of 8 weeks, their right testes were examined by light microscope. Results: In both STZ and fructose groups rat testes were found affected. There were germ cell depletion, tubular atrophy and thickening of blood vessel walls in both groups. Tubular atrophy was more severe in STZ group. In STZ group there were multinucleated giant cells in tubules, vacuolization in cytoplasms of Sertoli cells and inflammatory cell infiltration in interstitial tissue. Conclusion: We concluded that both STZ and fructose induced experimental diabetes lead to testicular atrophy in rats and this atrophy is more prominent in STZ group.Keywords: Experimental diabetes, Rat, Testis, Light microscopeTurkiye Klinikleri J Med Sci 2002, 22:173-178
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