ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Leptin, Neuropeptide Y And Obesity
Gönen DENİZ*, Şahan SAYGI**
* Ass.Prof.Dr., GATA, Department of Pharmacology,**Ass.Prof.Dr., GATA, Department of Analytical Toxicology, Ankara, TURKEY
Obesity is a highly prevalent disorder that is associated with high mortality rate from related diseases such as cardiovascular and metabolic diseases. It is caused by an imbalance between energy intake and energy expenditure, which is influenced with both environmental and genetic factors.The discovery of leptin has led to better understanding of the obesity. Leptin is a peripheral hormone produced by the adipocytes and is thought to play a key role in the regulation of energy balance. Leptin, the product of the obese gene, inhibits food intake, stimulates energy expenditure and reduces body weight possibly suppressing hypothalamic neuropeptide Y activity. Obesity in ob/ob mice is caused by a mutation in the ob gene resulting in a lack of functional leptin.Leptin acts as a satiety factor by binding to receptors in the hypothalamus and the plasma levels of leptin are highly correlated with body fatty mass. Its expression increases after food intake and decreases during fasting and diabetes.This review briefly summarizes the role of leptin and neuropeptide Y in the regulation of food intake and body weight.Keywords: Leptin, NeuropeptideY, ObesityTurkiye Klinikleri J Med Sci 2002, 22:217-220
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