ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
|
|
|
Rhabdomyolysis Associated With The Combined Use Of Simvastatinand Itrakonazol
Çetin ÇEVİK*, Murat ÇAKIR*, Dilek SOYSAL**, Arzu AVCI***,
Nevin GÜRGÖR****, S. Leyla ASLAN*****
* Asis.Dr., Atatürk Eğitim ve Araştırma Hastanesi 1 Dahiliye Kliniği,
** Uz.Dr., Atatürk Eğitim ve Araştırma Hastanesi 1 Dahiliye Kliniği,
*** Uz.Dr., Atatürk Eğitim ve Araştırma Hastanesi Patoloji Ünitesi,
**** Uz.Dr., Atatürk Eğitim ve Araştırma Hastanesi Nöroloji Kliniği,
*****Doç.Dr., Atatürk Eğitim ve Araştırma Hastanesi 3 Dahiliye Kliniği, İZMİR
A 71 year old man with diffuse myalgia mainly located to upper and lower limbs, markedly increased serum creatine kinase levels and elevated liver function tests was admitted to the hospital. Further evaluations revealed that he had rhabdomyolysis due to combined use of simvastatin and itraconazole. After withdrawal of his medications and forced diuresis he recovered clinically in the course of time. He was externeted with dietary instructions and dose monitorization of his risk profile.Myopathy associated with rhabdomyolysis and hepatotoxicity may result from the combined use and pharmacokinetic interaction between lipid lowering drugs that are metabolised by hepatic cytochrome P450 enzyme and drugs that are acting with inhibition of hepatic cytochrome P450 enzyme.Keywords: Rhabdomyolysis, Itraconazole, Simvastatin, Antilipemic AgentsTurkiye Klinikleri J Med Sci 2003, 23:150-153
|
|
|
|
|
