ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Leptin, Insulin And Diabetes
Gönen DENİZ*, Şahan SAYGI**
* Doç.Dr., GATA Tıp Fakültesi Tıbbi Farmakoloji AD,
** Doç.Dr., GATA Tıp Fakültesi Analitik Toksikoloji BD, ANKARA
Leptin is a hormone produced by adipocytes and is thought to play a key role in the control of body weight. The discovery of leptin raised the hopes of obese population. Leptin inhibits feeding, stimulates thermogenesis, and decreases body weight through distinct receptors in target organs, which controls food intake and energy metabolism. Its absence experimentally and clinically produces obesity. Adiposity and insulin resistance are important risk factor in diabetes mellitus. Obese individuals characteristically manifest insulin resistance and hyperinsulinemia, which predispose to glucose intolerance, diabetes, and cardiovascular disease. In humans, insulin stimulates leptin production in adipocytes. Recent studies suggest a complex relationship between leptin and insulin resistance. Leptin has been shown to increase insulin sensitivity and improve glucose metabolism. It normalizes the hyperglycemia and hyperinsulinemia in ob/ob mice at doses that do not decrease weight. Thus, leptin may play an important role in the diabetes.Keywords: Leptin, Insulin, Diabetes MellitusTurkiye Klinikleri J Med Sci 2003, 23:170-173
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