ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Tbars, Glutathione And Carnitine Levels In Human Brain Tumours
Saffet TÜZGEN*, Hüseyin SÖNMEZ**, Zeynep ÖZTÜRK***, Hakan EKMEKÇİ****,
Emine KÖKOĞLU*****
* Uz.Dr., İ.Ü.Cerrahpaşa Medical Faculty Department of Neurosurgery,
** Prof.Dr., İ.Ü.Cerrahpaşa Medical Faculty Department of Biochemistry,
*** Msc.Bio., İ.Ü.Cerrahpaşa Medical Faculty Department of Biochemistry,
**** Msc.Tıb.Bio., İ.Ü.Cerrahpaşa Medical Faculty Department of Biochemistry,
*****Uz.Dr., İ.Ü.Cerrahpaşa Medical Faculty Department of Biochemistry , İstanbul, TURKEY
Purpose: The aim of the present investigation was to determine the tissue lipid peroxidation (TBARS: thiobarbituric acid reactive substance), reduced glutathione (GSH) and carnitine levels in human brain tumours. Results: The mean carnitine, GSH and TBARS levels for tumourous group were found to be 0.011±0.0047 mg/mg protein, 0.03±0.01 mg/mg protein and 2.3±1.3 mmol/mg protein respectively versus 0.019±0.002 mg/mg protein, 0.0387±0.01 mg/mg protein and 0.62±0.2 mmol/mg protein for normal brain tissues.Carnitine and GSH levels were found to be significantly lower in human brain tumours (p<0.001, p<0.05) than in control group. Whereas the mean TBARS level of tumourous group was significantly higher than those of the control group (p<0.001).Conclusion: In conclusion, elevated tissue TBARS level may be due to the decreased levels of carnitine and GSH in human brain tumours.Keywords: Thiobarbituric Acid Reactive Substances, Glutathione, Carnitine, Brain NeoplasmsTurkiye Klinikleri J Med Sci 2003, 23:101-103
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