ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Effects Of Pentoxifylline Application On Tnf-a, Icam-1 Levels And On The Histology Of Liver In The Rabbits Exposed To Experimental Sepsis Model
Mustafa K. BAYAR*, Mustafa AKIN**, Azize BEŞTAŞ***, Nevin İLHAN****, İbrahim ÖZERCAN*****
* Doç.Dr., Fırat Üniversitesi Tıp Fakültesi Anesteziyoloji ve Reanimasyon AD,
** Uz.Dr., Fırat Üniversitesi Tıp Fakültesi Anesteziyoloji ve Reanimasyon AD,
*** Yrd.Doç.Dr., Fırat Üniversitesi Tıp Fakültesi Anesteziyoloji ve Reanimasyon AD,
***** Yrd.Doç.Dr., Fırat Üniversitesi Tıp Fakültesi Biyokimya AD,
***** Doç.Dr., Fırat Üniversitesi Tıp Fakültesi Patoloji AD, ELAZIĞ
Purgose: Inflammatory cytokines especially tumour necrosis factor-alfa (TNF-α) are released excessively and uncontrolled in sepsis. Intercellular adhesion molecule-1 (ICAM-1) which TNF-α provides it to be defined at endothelial cells and circulatory release is increased by it is held accountable from liver damage and dysfunction. Treatments included towards the modulation of inflammatory response is being used at sepsis. At this study the correlation between liver dysfunction, mortality and circulating ICAM-1 concentrations in sepsis during pentoxifylline application was searched.
Material and Methods: In the study, the rabbits were separated into 3 random groups. One hour after cecal ligation and puncture (CLP) at rabbits 50 mg/kg IV pentoxifylline to pentoxifylline group and serum saline to sepsis group was given. Control group received only laparotomy. Physical examination was noted 1 day before CLP and daily after operation. Biochemical studies were done 1 week before CLP and for three periods after operation. At the end of experiment tissue MDA levels at liver were measured and histological evaluation was done. During the experiment dying animals were noted and survive ration were calculated.
Results: At pentoxifylline group TNF-α, sICAM-1, lactate and tissue MDA levels were similar to sepsis group. Increase at AST and ALT levels were significant at sepsis group than pentoxifylline group. Histological differences of liver preparations were a little significant than control group. Survive ratios were not different at pentoxifylline group from sepsis group.
Conclusion: As results, no evident effect of pentoxifylline on modulation of inflammatory response and mortality was determined, but it has been that it decreased the histologic differences at liver and prevented liver dysfunction.Keywords: Pentoxifylline, Tumor Necrosis Factor, Intercellular Adhesion Molecule-1, Liver Diseases, mortalityTurkiye Klinikleri J Med Sci 2003, 23:135-140
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