ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Effect Of Pinealectomy Or Melatonin Administration Onplasma Zinc Levels Of Rats*
Cem Şeref BEDİZ*, A. Kasım BALTACI**, Rasim MOĞULKOÇ**, Ali ATEŞ***
* Doç.Dr., Dokuz Eylül Üniversitesi Tıp Fakültesi Fizyoloji AD, İZMİR
** Yrd.Doç.Dr., Selçuk Üniversitesi Tıp Fakültesi Fizyoloji AD,
*** Dr., Selçuk Üniversitesi Fen-Edebiyat Fakültesi Biyoloji Bölümü, KONYA
Objective: It was suggested that pineal neurohormon melatonin modulates the plasma zinc levels. Plasma zinc level decrease in pinealectomized mice showed by previous studies supports the significant relations between zinc and melatonin. In this study, the effects of melatonin deficiency and supplementation on plasma zinc levels were investigated. Materials and Methods: The study was done in Selcuk University Experimental Medicine Research and Application Center. Twenty-four adult male rats divided into 3 groups. Pinealectomy (Px) was applied to 8 rats. Melatonin was administered (3mg/kg/day sc.) to eight intact rats. Intact 8 rats were used as controls. Three weeks later, the rats were decapitated and plasma zinc and melatonin levels were determined. Results: The plasma zinc level was higher in melatonin administered rats than both control and pinealectomized groups (P<0.01). Similar parameters of Px experimental group were significantly lower than both melatonin administered and control groups (P<0.01). While plasma melatonin levels were higher in melatonin administered group in comparison to control and pinealectomized groups (P<0.01), plasma melatonin levels of Px experimental group were significantly lower than both control and melatonin administered groups (P<0.01). Conclusion: The results of this study suggest that while pinealectomy suppresses plasma zinc levels significantly, melatonin supplementation augments the plasma zinc levels significantly in rats.Keywords: Melatonin, Zinc, RatsTurkiye Klinikleri J Med Sci 2002, 22:101-104
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