ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Utility Of Tl–201 And Ga–67 Scintigraphyon Clinical Management Of Cancer Patients
Recep BEKİŞ*, Gamze ÇAPA KAYA*, Berna DEĞİRMENCİ**, Erkan DEREBEK**, Hatice DURAK***
* Uz.Dr., Dokuz Eylül Üniversitesi Tıp Fakültesi Nükleer Tıp AD,** Doç.Dr., Dokuz Eylül Üniversitesi Tıp Fakültesi Nükleer Tıp AD,*** Prof.Dr., Dokuz Eylül Üniversitesi Tıp Fakültesi Nükleer Tıp AD, İZMİR
Thallium 201 (Tl–201) and Gallium 67 (Ga–67) are nonspecific tumor markers, which have been widely used in tumor imaging.Purpose: The purpose of this retrospective study was to investigate the utility of Tl–201 and Ga–67 tumor scintigraphy on clinical management and follow–up of the patients with suspected primary or recurrent tumors. Materials and Methods: Tl–201 and Ga–67 scintigraphy were performed in 41 and 29 patients respectively, with suspected primary or recurrent solid tumors. Tl–201 tumor images were obtained 20 minutes and 2 hours after the 111 MBq of Tl–201 injection. Ga–67 imaging was performed 48 hours and 72 hours after the 370 MBq of Ga–67 injection. Planar views and whole body images were obtained. From the clinicians point of view, the following parameters were used for evaluating the utility of these two tracers while deciding on clinical management. Determinative: If the clinicians made their decisions according to only scintigraphy results and clinical findings. Indeterminative: If the clinician needed any further radiological examinations for clinical decision. Consistent: If the scintigraphic results were consistent with clinical follow–up and histopathology. Inconsistent: If the scintigraphic results were not consistent with histopathology. Results: Tl-201 tumor scintigraphy was determinative in 24 (59 %) of 41 patients who underwent Tl-201 tumor scintigraphy and indeterminative in 17 (41 %) patients. In 34 (83 %) patients, Tl-201 tumor scintigraphy was consistent, in 7 (17 %) patients it was inconsistent. Tl-201 tumor scintigraphy of all patients in determinative group was consistent. Tl-201 tumor scintigraphy in indeterminative group was consistent in 10 (24 %) patients, inconsistent in 7 (17 %) patients. Ga-67 scintigraphy was determinative in 14 (48 %) patients of 29 patients who underwent Ga-67 scintigraphy and indeterminative in 15 (52 %) patients. In 27 (93 %) patients, Ga-67 scintigraphy was consistent, in 2 (7 %) patients was inconsistent. Ga-67 scintigraphy of all patients in determinative group was consistent. Ga-67 scintigraphy in indeterminative group was consistent in 13 (45 %) patients, inconsistent in 2 (7 %) patients.Conclusion: We concluded that though Tl–201 scintigraphy showed more inconsistent results, it is more determinative for the clinicians than Ga–67 scintigraphy on clinical management of patients with cancer. This may be releated to the limited availability and low specificity of Ga–67 scintigraphy and it may also be due to increased popularity of Tl–201 scintigraphy between clinicians and nuclear medicine physicians in the recent years.Keywords: Ga-67, Tl-201, Clinical Utility, CancerTurkiye Klinikleri J Med Sci 2002, 22:129-132
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