ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Plasma Angiotensin Converting Enzyme Activity And The Levels Of Plasma And Erythrocyte Zinc In Hypertensive Diabetic Individuals
Özlem BALCI EKMEKÇİ*, Orkide DONMA**, Akın AYDEMİR***, Semra ÖZDEMİR****,Nazif BAĞRIAÇIK*****
* Dokt.Öğr.Msc.Tıb.Bio., İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Biokimya AD,** Prof. Dr., İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Biokimya AD,*** Phd.Dr., İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Biokimya AD,**** Phd., İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Biofizik AD,***** Prof. Dr., İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi İç Hastalıkları AD, İSTANBUL
Hypertension, evaluated as the elevation of systemic arterial pressure above the defined values, is a risk factor for many diseases particularly for cardiovascular diseases. Angiotensin Converting Enzyme (ACE); a component of the renin-angiotensin system has an important role in the regulation of blood pressure and converts Angiotensin I to Angiotensin II, a potent vasoconstrictor. Zinc (Zn), one of the trace elements in the human body, has important biological functions and has been found in the catalytic site of many enzymes including ACE. The aim of this research is to evaluate plasma ACE activities, plasma and erythrocyte Zn concentrations in the hypertensive diabetic individuals. It has been investigated whether there is any difference between the values obtained for these parameters in the hypertensive diabetics compared to the normotensive diabetic individuals, the control group. In this study, the plasma ACE activities, plasma and erythrocyte Zn levels of twenty-three hypertensive diabetic and twenty-five diabetic individuals were evaluated. In the hypertensive diabetic individuals, plasma ACE, Zn and erythrocyte Zn values were 61.4 ± 5.3 U/L, 9.4 ± 0.4 mol/L ,123.5 ± 5.0 mol/L respectively; in the diabetic individuals these values were found as 43.8 ± 4.6 U/L,12.6 ± 0.6 mol/L,139.5 ± 6.0 mol/L.It was concluded that while ACE activities in hypertensive diabetics were significantly higher than diabetic individuals, plasma and erythrocyte Zn levels were lower than those in the control group.Keywords: Diabetes Complications, (ACE)Peptidyl-Dipeptidase A, ZincTurkiye Klinikleri J Med Sci 2002, 22:553-556
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