ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Ubiquitin System
Yıldız GÜNEY*, Ayşe BİLGİHAN**
* Dr., Gazi Üniversitesi Tıp Fakültesi Biyokimya AD, ** Doç.Dr., Gazi Üniversitesi Tıp Fakültesi Biyokimya AD, ANKARA
Ubiquitin is a highly conserved, heat stable, 76 amino acid polypeptide, though to be present in all eukaryote cell types and is responsible for an ATP-dependent proteolytic pathway. Ubiquitin covalently attaches to target proteins with the help of ubiquitin activating enzyme (E1), ubiquitin conjugating enzyme (E2), and recognizing protein (E3). Polyubiquitinylated proteins are than (recognized and) degraded by the 26S proteasome. Ubiquitin-mediated degradation of regulatory proteins plays important roles in the control of cell cycle progression, signal transduction, transcriptional regulation and apoptosis. Ubiquitin may additionally be involved in the pathogenesis of various diseases, determination of ubiquitin forms in human serum could be important to find possible clinical applications.Keywords: Ubiquitin, Proteasome Endopeptidase Complex, Radiation, IonizingTurkiye Klinikleri J Med Sci 2002, 22:616-619
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