ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Chemokines And Diseases
Funda Erkasar ÇITAK*, Elvan Çağlar ÇITAK**, Ceyda KARADENİZ***
* Uz.Dr., LÖSEV-LÖSANTE Lösemili Çocuklar Hastanesi,** Arş.Gör.Dr., Gazi Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları AD,*** Prof.Dr., Gazi Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları AD, ANKARA
Chemokines are a superfamily of pro-inflammatory polypeptide cytokines that selectively attract and activate different cell types. Many pathophysiological conditions require the participation of chemokines including inflammation, infection, tissue injury, allergy, cardiovascular diseases as well as malignant tumours. Now, more than 30 members of chemokine superfamily and 15 members of chemokine receptor have been identified. The true nature of the influence that chemokines have upon a particular response and the identification of critical chemokines as therapeutic targets can only be determined by thorough analysis of appropriate responses in animal models. Because of the diversity of chemokine production, the number and type of chemokines, and the various binding pattern for multiple receptors, the identification and elucidation of mechanism will be difficult. Future studies into the function of chemokines should investigate the specific functions of individual chemokines during various phases of disease. Only then can their true functions be elucidated. This review will attemp to describe what is understood about chemokine in light of recent discoveries.Keywords: Chemokines, Function and diseasesTurkiye Klinikleri J Med Sci 2002, 22:210-216
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