ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Lipid Peroxidation And Antioxidant Status In Pre-eclampsia And Healthy Pregnancy
Tevfik NOYAN*, M.Ramazan ŞEKEROĞLU**, Haluk DÜLGER*, Mansur KAMACI***
* Yrd.Doç.Dr., Yüzüncü Yıl Üniversitesi, Tıp Fakültesi Biyokimya AD, ** Doç.Dr., Yüzüncü Yıl Üniversitesi, Tıp Fakültesi Biyokimya AD,*** Prof.Dr., Yüzüncü Yıl Üniversitesi, Tıp Fakültesi Kadın Hastalıkları ve Doğum AD, VAN
Pre-eclampsia (preeclamptic toxemia) is a pregnancy complication that occurs in the late 2nd or 3rd trimesters of pregnancy and is a major cause of maternal and fetal mortality. It has been suggested that preeclampsia is associated with oxidative stress, defined as an imbalance between prooxidant and antioxidant forces in favor of prooxidants, leading to potential cell or tissue damage. In this study, we aimed to investigate the effect of lipid peroxidation in the occurence of pre-eclampsia. For this aim, serum and erythrocyte malondialdehyde (MDA), serum uric acid and lipid levels were measured in 25 pre-eclamptic, 25 normal healthy pregnant and 25 non-pregnant healthy women as control group. When compared with control group, in the pre-eclamptic group, the levels of serum and erythrocyte MDA, serum uric acid, triglyceride, cholesterol, VLDL(very low density lipoprotein)-cholesterol were found statistically significiantly higher (p<0.01). Also, in normal healthy pregnant when compared with control group, the levels of serum triglyceride, cholesterol, HDL(high density lipoprotein)-cholesterol, LDL(low density lipoprotein)-cholesterol and VLDL-cholesterol were found significantly statistically higher (p<0.01), but there were no significiant differences in levels of serum and erythrocyte MDA and uric acid between control and healthy pregnant groups (p>0.05). Our results suggest that the balance between oxidant and antioxidant systems may be changed in the pre-eclampsia as compared to healthy pregnant.Keywords: Pre-eclampsia, Lipid peroxidation, Oxidative damageTurkiye Klinikleri J Med Sci 2002, 22:461-465
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