ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Effects Of Deoxycorticosteron, Ouabain And Combinations Of Deoxycorticosteron And Ouabain On Blood Pressure In Rats
Gül İLBAY*, Ayşe DOĞAN**
* Yrd.Doç.Dr., Kocaeli Üniversitesi Tıp Fakültesi Fizyoloji AD, KOCAELİ
** Prof.Dr., Çukurova Üniversitesi Tıp Fakültesi Fizyoloji AD, ADANA
An increase in ouabain like humoral agents has been reported in deoxycorticosterone (DOC)-salt hypertensive rats. In order to test the hypothesis that ouabain may amplify the hypertensive action of mineralocorticoids, we studied effects of administration of ouabain and DOC alone and in combination on blood pressure for up to five weeks in uninephrectomized rats drinking 0.9 % NaCl. Normotensive, male Wistar rats were unilaterally nephrectomized. After a week of recovery from surgery, graded doses of DOC (5 mg, 10 mg), ouabain (1 mg, 2 mg) and a combination of DOC (5 mg) and graded doses of ouabain (0.05 mg, 0.1 mg, 0.25 mg ve 1 mg) were injected into rats weekly for 5 weeks. DOC and ouabain were dissolved in 1 ml olive oil and injected s.c. Rats in control groups received 1ml olive-oil only. All rats drank a 0.9 % NaCl solution, their systolic blood pressures were monitored weekly. It was observed that blood pressure of rats given 5 mg DOC or ouabain alone was not significantly different compared with control rats. However, the blood pressures of rats given the larger dose DOC (10 mg) and the combinations of DOC (5 mg) and ouabain (0.25, 1 mg) were markedly higher than control rats. The present results show that long-term administration ouabain does not produce hypertension, whereas a combination of small dose DOC and ouabain produce hypertension like large dose DOC.Keywords: Blood pressure, Desoxycorticosterone, OuabainTurkiye Klinikleri J Med Sci 2002, 22:505-509
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