ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Waldenstrom's Macroglobulinemia
Cengiz BEYAN*, Kürşad KAPTAN**, Türker ÇETİN***
* Doç.Dr., GATA Hematoloji BD, Öğr.Üy.,
** Uz.Dr., GATA Hematoloji BD,
*** Yrd.Doç.Dr., GATA Hematoloji BD, Öğr.Üy., ANKARA
Waldenstrom's macroglobulinemia (WM) is an uncommon B cell malignancy that resembles other B cell malignancies, such as multiple myeloma and chronic lymphocytic leukemia. Clinical course of WM varies widely. Although the median survival of patients are 5 years, it is more than 10 years at least 20% of them. WM is diagnosed when a bone marrow biopsy reveals malignant B-lymphocytes arrested at the plasmacytoid lymphocytic stage of the maturation process and when high levels of IgM are found in the serum blood. Common clinical features include anemia, abnormal bleeding, and hyperviscosity. Some of the patients present with lymphadenopathy or splenomegaly. Alkylating agents have been the most common chemotherapy agents used to treat WM. However, nucleoside analogues are being used more frequently with promising results.Keywords: Waldenstrom MacroglobulinemiaTurkiye Klinikleri J Med Sci 2002, 22:87-93
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