ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
|
|
|
|
ORIGINAL RESEARCH ARTICLES |
Effects Of Sialoadenectomy And Flutamide Treatment In Pregnant Rats On The Levels Of Testosterone, Fsh, Lh And Testis In Male Rats
M. Aydın KETANİ*, Yusuf NERGİZ**, Ö. Mukaddes ELİTOK***
* Yrd.Doç.Dr., Dicle Üniversitesi Veteriner Fakültesi Histoloji ve Embriyoloji AD,
** Prof.Dr., Dicle Üniversitesi Tıp Fakültesi Histoloji ve Embriyoloji AD,
*** Arş.Gör.Dr., Dicle Üniversitesi Veteriner Fakültesi İç Hastalıklar AD, DİYARBAKIR
In this study our purpose is to determine the effect of sialoadenectomy (maternal epidermal growth factor deficiency) and antiandrogen (Flutamide) treatment in pregnant rats on body and reproductive organ weights, serum levels of testosterone, Follicle Stimulating Hormone (FSH), Luteinizing Hormone (LH) and testis of male rats postpartum.Sexually mature fourty female Spraque-Dawley rats were used. They were divided into four groups; Group-I: Control group, Group-II: Sialoadenectomized (Sx), Group-III: Flutamide treated (F), Group-IV: Sialoadenectomized + Flutamide treated (Sx+F).Body and reproductive organ weights were markedly reduced in Sx, F, Sx+F groups compared with control group. LH and FSH levels were normal in all groups but circulating testosterone levels significantly increased in Sx, F, Sx+F groups.Histological examination revealed that spermatogenesis arrest at spermatocyt-II level in Sx group, spermatogenesis arrest at spermatocyt-I level in F group, typically hypospermatogenesis and testicular atrophy in Sx+F group.As a result, maternal epidermal growth factor deficiency performed by sialoadenectomy and maternal flutamide treatment caused retardation in the development of body and reproductive organs, increasing levels of testosterone, degenerative changes in testes in male rats postpartumKeywords: Rats, Adenoidectomy, Flutamide, Testosterone, Follicle Stimulating Hormone, Luteinizing Hormone, Testis, HormonesTurkiye Klinikleri J Med Sci 2002, 22:1-7
|
|
|
|
|
