ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Effects Of Tibolone And Other Hormon Replacement Therapy Protocols On Serum Lipoprotein Levels In Postmenopausal Women
Neslihan HAZAR*, Zerrin GÖKAY*, Güzin BAŞÇI*, Selma ORANSOY*, Oya GÖKMEN** Dr. Zekai Tahir Burak Kadın Hastanesi, ANKARA
In this study the authors’ aim was to compare the effect of tibolone and other hormon replacement therapy protocols on the serum lipoprotein concentrations in postmenopausal women. A total of 160 healthy postmenopausal women aged 40- 60 years were randomly assigned in seven groups to take hormon replacement therapy. In group 1, there were fourty women who were treated with tibolone 2.5 mg/day. In each remaining group there were twenty women who were treated with the following regimes consequently; conjugated equine estrogen (CEE) 0.625 mg/day plus consecutive medroxyprogesterone acetate (MPA) 5 mg/day, CEE 0.625 mg/day plus consecutive dydrogesterone (DD) 10 mg/day, estradiol 17 b 50mcg/day plus consecutive DD 10 mg/day, estradiol 17 b 50mcg/day plus consecutive MPA 5 mg/day, estradiol 17 valerat 2mg plus consecutive cyproterone acetate 1 mg/day. Twenty women who refused to take hormon replacement therapy, were accepted as the control group. Fasting serum lipoprotein profile which were composed of High Density Lipoprotein Cholesterol (HDLC), Low Density Lipoprotein Cholesterol (LDLC), Very Low Density Lipoprotein Cholesterol (VLDLC), Total Cholesterol (TC), Triglyceride (TG) were estimated before and on the twenteeth month of the treatment.In tibolone treated group a significant decrease in TG, VLDLC and HDLC (p<0.001) but an increase in LDLC were noticed (p<0.05). After the results were compared, tibolone was found to be causing the highest decrease in TG levels (p<0.001).Decrease in TG and VLDLC levels gave a hope that tibolone treatment may have a beneficial effect on cardiovascular risk and it can be an alternative therapy especially in postmenopausal women with high TG levels, but on the otherhand, unwanted decrease in HDLC and elevation in LDLC indicates more studies to be performed to clear the risk/benefit ratio of the therapy.Keywords: Menopause, Hormone Replacement Therapy, tibolone, Lipoproteins, LipidsTurkiye Klinikleri J Med Sci 2002, 22:8-13
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