ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Nerve Repair And Grafting (review Of The Literature)
Gülden AVCI*, Mithat AKAN*, Serkan YILDIRIM*, Tayfun AKÖZ*
* Dr., Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi Plastik ve Rekonstrüktif Cerrahi Kliniği, İSTANBUL
Peripheral nerve injuries can result from mechanical, thermal, chemical reasons or pathological etiology. Failure to restore these damaged nerves can lead to the loss of muscle function, impaired sensation and painful neuropathies. Our knowledge of biological mechanisms regulating posttraumatic nerve regeneration has increased substantially with respect to the role of neurotrophic and neurite promoting substances, but new molecular biological knowledge has so far gained very limited clinical applications.Techniques for clinical approximation of severed nerve ends have reached an optimal technical refinement and new concepts are needed to further increase the results from nerve repair. A greater awareness and understanding of the nerve ultrastucture, as well as the underlying mechanisms of the regenerative process and those factors detrimental to nerve regeneration, will assist in the successful repair of nerve injury. Currently, the therapeutic approaches taken toward the patient with peripheral nerve injury change continuously. Sophisticated advanced in technology, cellular and molecular neurobiology and electron microscopy will doubtless optimize reconstructive strategies in treating nerve injury. This paper reviews the cellular, biochemical, and ultrastructural elements of nerve injury, repair and grafting and the rationale for current reconstructive strategies and techniques.Keywords: Nerve regeneration, Peripheral NervesTurkiye Klinikleri J Med Sci 2002, 22:428-437
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