ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Plasma Viscosity Levels During Oral Glucose Tolerance Test
Dildar KONUKOĞLU*, Meltem ERCAN**, Özden SERİN***
* Prof.Dr., İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi Biyokimya AD,
** Ph.Dr., İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi Biyofizik AD,
*** Uz.Dr., Taksim İlkyardım Hastanesi Biyokimya Laboratuvarı, İSTANBUL
Purpose: The aim of this study was to investigate the effect of postprandial hyperglycemia, as a predictor of early atherosclerosis on plasma viscosity.Material and Methods: Forty female subjects were involved in this study, and were performed oral glucose tolerance test. These subjects were classified as normal (n:15, mean age:46.5±15.4 years), impaired (n:13, mean age:43.5±10.6 years) and diabetic (n:12, mean age:48.8±7.5 years) glucose tolerance according to the World Health Organization Criteria. Plasma viscosity was measured in subjects at baseline and 60 and 120 min after glucose loading , using Harkness capillary viscometer.Results: The baseline plasma viscosity was significantly higher in both subjects with impaired and diabetic glucose tolerance (p<0.001 and p<0.001, respectively) than in subjects with normal glucose tolerance. 60 min. after glucose loading, plasma viscosity was significantly higher than baseline plasma viscosity levels in all groups (p<0.001, p<0.001 and p<0.001, respectively). While in subjects with normal glucose tolerance plasma viscosity at 120 minute after glucose loading returned to baseline levels, in subjects with impaired and diabetic glucose tolerance plasma viscosity at 120 minute was significantly higher than baseline. There was a positive correlation between plasma and glucose(r:0.45, p<0.001) and cholesterol levels (p<0.41, p<0:001). Conclusions: Our results suggest that hyperglycemia induced an increase in plasma viscosity and the elevated plasma viscosity levels may be related to the early atherosclerosis processKeywords: Glucose Tolerance Test, Oral glucose tolerance test, Atherosclerosis, Plasma, Diabetes mellitusTurkiye Klinikleri J Med Sci 2002, 22:397-400
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