ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Light And Electron Microscopic Study Of Maternal Application Ofhigh Dose Vitamin A On Renal Cortex
Hüseyin AKTUĞ*, Naime AKDEDE**, Mine YURTSEVEN***, Ayşegül UYSAL****,
Serap USLU**, Gülperi ÖKTEM*****
* Uzm.Dr., Ege Üniversitesi Tıp Fakültesi Tıp Fakültesi Histoloji ve Embriyoloji AD,
** Arş.Gör., Ege Üniversitesi Tıp Fakültesi Tıp Fakültesi Histoloji ve Embriyoloji AD,
*** Prof.Dr., Ege Üniversitesi Tıp Fakültesi Histoloji ve Embriyoloji AD,
**** Doç.Dr., Ege Üniversitesi Tıp Fakültesi Histoloji ve Embriyoloji AD,
***** Dr., Ege Üniversitesi Tıp Fakültesi Histoloji ve Embriyoloji AD, İZMİR
Purpose: It is well known that Vitamin A plays a critical role in organogenesis and is an important factor affecting nephrogenesis. In the studies conducted through creating Vitamin A deficiency, some developmental malformations including kidney were demonstrated. It was reported that number of fetus glomerulus decreased due to Vitamin A deficiency during pregnancy. In this study, in case of application of high dose Vitamin A, in newborn rats the morphometric change within the number of glomeruls examined and light and electron microscopic examination of renal corpuscle structure was carried out.Material and Methods: Rats were divided into three groups; control, group I (40000 IU/kg) and II (160000 IU/kg) experiment group. Application of medicine (Vitamin A); embryonic 8 day intraperitoneal single dose. Kidneys taken from newborn rats were examined morphologically with the light microscope. Preparations made were followed through routine electron microscope and the fine structure of renal corpuscle considered. In order to show the glomerul rates of control group and the group that Vitamin A applied, semithin cross-sections were dyed with toluidin blue.Results: In these cross-sections, a proportionally apparent increase was detected in the number of glomerules between control group and the rats that Vitamin A applied (26%).Keywords: Retinol Acetate, Microscopy, Electron, KidneyTurkiye Klinikleri J Med Sci 2002, 22:369-372
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