ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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The Efficacy Of Antibiotic Prophylaxis Intransrectal Biopsy Of Prostate: A Prospective Randomized Study Of Single Dose Oral Fluoroquinolone Versus Trimethoprim-sulfamethoxazole
Kenan İSEN*, Bora KÜPELİ*, Zafer SINIK*, Hasan BİRİ*, Sinan SÖZEN*, İbrahim BOZKIRLI*
* Dr.,Dept. of Urology, Gazi University Faculty of Medicine, Ankara, TURKEY
We studied 110 patients undergoing transrectal biopsies to determine the need of antibiotic prophylaxis for the biopsy of prostate and to compare the efficacy of single dose (400 mg) oral ofloxacin versus single dose (160 mg + 800 mg) oral trimethoprim - sulfamethoxazole. Patients were randomly assigned into 3 groups. Of the 23 patients who had not received antibiotic prophylaxis, urinary infection was found in 6 (26.08%). Of the 42 patients who received ofloxacin, urinary infection was found in 2 (4.76%) and of the 45 patients who received trimethoprim - sulfamethoxazole, urinary infection was found in 3 (6.66 %). There were a reduction in urinary infection in groups which received antibiotic regimens, however, it was not a statisticially significant reduction in urinary infection (p >0.05, p> 0. 05). This result may be due to the low numbers of patients in each group and and the subject should be investigated in larger groups.
Our study indicate that the prophylactic antibiotic causing low rate of clinical post-biopsy infections. Although the selection of the antibiotic regimen depends on the clinical practice, the use of a fluoroquinolone or trimethoprim - sulfamethoxazole for this purpose seems to be effective, practical and economical.
Keywords: Transrectal prostate biopsy,
Antibiotic prophylaxis, Ofloxacin,
Trimethoprim-Sulfamethoxazole, Infection
Turkiye Klinikleri J Med Sci 1998, 18:196-199
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