ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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The Pathogenesis Of Acute Rheumatic Fever
Yavuz BAYKAL*, Kenan SAĞLAM*, Mustafa TURAN**
* Doç.Dr.,GATA İç Hastalıkları BD,
** Doç.Dr.,GATA Hidroklimatoloji AD, ANKARA
Although the pathogenesis of acute rheumatic fever (ARF) completely understood, there are some points that remain obscure. The essential ingredient appears to be an induvidual with inherited immunological abnormalities encountering a strain of group A streptococcus (GAS) with rheumatogenic potential, possibly related to the presence of antigens cross-reactive with human tissue. Abnormal processing of GAS antigens and/or abnormal expression of self antigens result an exagerated cellular immune response with consequent damage to host tissue and the production of cross-reactive antibodies. Superantigens and copathogens may also play a role.
Keywords: Acute rheumatic fever
Turkiye Klinikleri J Med Sci 1998, 18:231-235
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