ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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The Immunogenetic Of Primary Sclerosingcholangitis And Medical Treatment
Zafer ÇALIŞKANER*, Salih PAY*, Yavuz BAYKAL**
* Dr.,Gülhane Askeri Tıp Akademisi, İç Hastalıkları BD,
** Doç.Dr.,Gülhane Askeri Tıp Akademisi, İç Hastalıkları BD, ANKARA
Primary sclerosing cholangitis is a chronic cholestatic liver disease characterized by fibro-obliterative inflammation of the intra and extrahepatic bile ducts; in%70 cases, it is associated with inflammatory bowel disease. The disease usually runs a progressive coarse, ultimately leading to biliary cirrhosis, hepatic failure and sometimes cholangiocarcinoma, with median survial of 12 year after diagnosis. As yet, the etiology of primery sclerosing cholangitis remains unknown, although several studies have implicated immunogenetic factors as important pathogenetic mechanisms.
Besides liver transplantation for patients with end stage cirrhotic liver disease and endoscopic therapy for patients with dominant extrahepatic bile duct strictures, recent studies have also shown promising results of drug therapy with ursadeoxycolic acid in the treatment of primary sclerosing cholangitis.
Keywords: Primary sclerosing cholangitis,
Immunogenetic
Turkiye Klinikleri J Med Sci 1998, 18:285-291
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