ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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The Demonstration Of Nervous Elements In The Ureteral Wall Of Guinea-pig By Using The Antibodies Against Pgp 9.5 And Calcitonin Gene-related Peptide (cgrp)
S. Tuna Karahan*
* Doç.Dr.,Ankara Üniversitesi Tıp Fakültesi Anatomi AD, ANKARA
Ureters are channels, which connect pelvis renalis to the urinary bladder. The urine is transported through the ureter by peristalsis. The occurrence of peristaltic waves is tried to be explained by different mechanisms. The presence of a pacemaker in the ureter, the nerve cell containing plexus which resembles the one in the gut, the impulses which originate from the lower ureter and urinary bladder and the affects of neuromediators which are released from the afferent nerve terminals are some of these mechanisms. In this study, whole-mount preparations of five guinea pigs’ ureters were used. The immunohistochemical reaction was performed by using the antibodies against PGP 9.5 which is a cytoplasmic protein in the peripheric nerves and against calcitonin generelated peptide (CGRP) which is released from the afferent nerve terminals and the nerve structures in the ureter were visualised. While PGP 9.5 like immunoreactivity was seen in the nerve cell bodies, no CGRP like immunoreactivity in nerve cells was observed. CGRP like immunoreactivity showing nerves were fewer than the PGP 9.5 like immunoreactivity showing ones. These findings suggest that other neuromediators than CGRP may play a role in the occurrence of peristalsis in the ureter.
Keywords: Guinea-pig, Ureter, Innervation,
Immunohistochemistry, PGP 9.5, CGRP
Turkiye Klinikleri J Med Sci 1998, 18:384-387
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