ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Interferon Receptors Systems And Signal Transduction
Nuray ASLAN*, Ayşegül AYYILDIZ**
* Dr.,Ankara Üniversitesi Hepatoloji Enstitüsü
** Dr.,Ankara Üniversitesi Tıp Fakültesi Biyokimya AD, ANKARA
Since the first discovery in 1957, interferons have been medically used for their antiprolipherative, antiviral and immunoregulatory functions. Interferons are classified into type I (a/b) and type II (g). Both types mediate the biological response by binding to their specific receptors on target cells and causing a rapid increase of gene transcription. On the way from the receptor to the cell nucleus, the intracellular signalling molecules that play role are the Janus Family Kinases (JAK) and the signal transducer activators (STAT).
This article is a review of the physiochemical reaction mechanisms related to functioning of JAK-STAT and other signalling molecules to act on the biological response to interferon type I and type II receptors.
Keywords: Interferon receptors, signal transduction,
JAK, STAT, Tyk-2
Turkiye Klinikleri J Med Sci 1998, 18:351-359
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