ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
|
|
|
|
The Pathogenesis Of Atherosclerosis
Yavuz BAYKAL*, Ahmet TÜZÜN**, Fikri KOCABALKAN***
* Doç.Dr.,GATA İç Hastalıkları BD, ** Dr.,GATA İç Hastalıkları BD,*** Prof.Dr.,GATA İç Hastalıkları BD, ANKARA
Atherosclerosis, a common and complex disease, result from multiple interactions among injurious stimuli and the healing reperative responses of arterial wall. After endothelial, direct cell-cell interaction, and secretion of chemotactic and growth factors resulting from endothelial cell dysfunction, induce recruitment of monocytes to subintimal regions, smooth muscle cell proliferation, and increased synthesis of matrix proteins. The recruited monocytes become macrophage, accumulate lipid, and ultimately become foam cell. Togather with accompanying T lymphocytes these changes represent the fatty streak, an early histopathological change indicating atherosclerosis. Progression of this atherosclerosis lesion is marked the accumulation of alternating layers of smooth muscle cells and lipid-laden macrophages.
Keywords: Atherosclerosis, pathogenesis
Turkiye Klinikleri J Med Sci 1998, 18:360-368
|
|
|
|
|
