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Trophic Effects Of Octreotide On Defunctioned Small Bowel In Rats
Alaeddin DİLSİZ*, Aytekin KAYMAKÇI*, Murad AKTAN**,
H.İbrahim KARABACAK***, Adil KARTAL****
* Dr.,Selçuk Üniversitesi Tıp Fakültesi Çocuk Cerrahisi AD,
** Dr.,Selçuk Üniversitesi Tıp Fakültesi Histoloji ve Embriyoloji AD,
*** Dr.,Selçuk Üniversitesi Tıp Fakültesi Farmakoloji AD,
**** Dr.,Selçuk Üniversitesi Tıp Fakültesi Genel Cerrahi AD, KONYA
In this study, our aim was to investigate the effect of octreotide (OCT, a long-acting somatostatin analogue) in the defunctioned small bowel of rat.
The study was performed on isolated loop of small bowel in 30 rats. A vascularized jejunal loop, 15 cm in length, was prepared and separated from the intestine and its two ends brought out through the abdominal wall just as mucous fistula. Intestinal continuity was restored by jejunojejunostmy. The rats were divided into two groups, each of which had 15 animals. All groups had parenteral nutrition solution isocalorically and isonitrogenically by oral route. In addition to this, the second group received octreotide acetate (5 mg/kg/day). The first group acted as the control. At the end of the third week, all rats were under laparotomy. The isolated loop was resected for histological examination for length of villi and mucin (the number of goblet cells) were measured. In the second group, the length of villi increased significantly (p<0.001) in isolated loops compared with controls, but the number of goblet cells were decreased significantly (p<0.001).
In conclusion, OCT has positive trophic effect on isolated bowel villi but no effect on goblet cells.
Keywords: Octreotide, Defunctioned small bowel,
Trophic effect
Turkiye Klinikleri J Med Sci 1998, 18:398-401
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