ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Effect Of Simvastatin On In Vitro Platelet Aggregationin Hypercholesterolemic Patients
Hasan Altunbaş*, Ayşegül Odabaşoğlu**, Mustafa Kemal BALCI***, Gürhan Günay**,
İhsan Karadoğan****, Levent Ündar*****, Ümit KarayalçIn******
* Uz.Dr.,Akdeniz Üniversitesi Tıp Fakültesi Endokrinoloji ve Metabolizma Hastalıkları,
** Dr.,Akdeniz Üniversitesi Tıp Fakültesi İç Hastalıkları AD,
*** Doç.Dr.,Akdeniz Üniversitesi Tıp Fakültesi Endokrinoloji ve Metabolizma Hastalıkları,
**** Yrd.Doç.Dr.,Akdeniz Üniversitesi Tıp Fakültesi Hematoloji BD,
***** Prof.Dr.,Akdeniz Üniversitesi Tıp Fakültesi Hematoloji BD,
****** Prof.Dr.,Akdeniz Üniversitesi Tıp Fakültesi Endokrinoloji ve Metabolizma Hastalıkları, ANTALYA
Statins which inhibit HMG CoA reductase are used in the treatment of hypercholesterolemia. They effectively reduce plasma cholesterol level and decrease risk of myocardial infarction and stroke. Some authors reported that statins also inhibit platelet aggregation. But, results of these studies are controversial. In this study, we investigated the effect of simvastatin on in vitro platelet aggregation in patients with primary hypercholesterolemia. Eleven adult hypercholesterolemic patients (with or without hypertriglyceridemia) were enrolled in the study (8 female, 3 male; mean age 51.5±5.5 years; total cholesterol 288±37 mg/dL). Simvastatin (10 mg/day) was started to all patients. Blood samples for platelet aggregation and lipid parameters (total cholesterol, HDL-, LDL-, VLDL-cholesterol and triglyceride) were obtained at the beginning of the study and after two months. In vitro platelet aggregation (induced by adenosine diphosphate (ADP), collagen and ristocetin) was measured by whole blood impedance aggregometer. Therapy with simvastatin didn’t cause a significant decrease of plasma level of total cholesterol, whereas it reduced level of LDL-cholesterol p=0.009) and increased level of HDL-cholesterol (p=0.03). On the other hand, the change of the parameters of platelet aggregation was not statistically significant.Keywords: Hypercholesterolemia, Platelet aggregation,
Statins, SimvastatinTurkiye Klinikleri J Med Sci 1999, 19:25-29
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