ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Hyperprolactinemia: Diagnosis And Treatment
Arif YÖNEM*, Mustafa KUTLU**
* Uz.Dr.,GATA Endokrinoloji ve Metabolizma Hastalıkları BD,
** Prof.Dr.,GATA Endokrinoloji ve Metabolizma Hastalıkları BD, ANKARA
Hyperprolactinemia is a common finding in clinical endocrine practice and, with the exclusion of drugs, a prolactinoma is the most common cause. In women, the presenting symptoms are most often irregular menses and/or galactorrhea, infertility and hirsutism whereas in men it causes some degree of decreased libido, hypogonadism or erectile dysfunction. The measurement of serum prolactin level is important for the diagnosis and this measurement should be done in three separate blood samples taken in thirty minutes intervals. Although there is no precise correlation between serum prolactin levels and its underlying cause, the levels exceeding 100 mg/L should be viewed as a clue for the presence of prolactinoma. High resolution computerized tomography or magnetic resonance imaging are also useful tools for the demonstration of the prolactinomas. A number of synthetic ergot derivatives, the leading bromocriptine, are highly effective in reducing serum prolactin levels, irrespective of its causes. It has also been shown that these agents can reduce the tumor size in prolactinomas. In the treatment of prolactinoma, the most important cause of pathological hyperprolactinemia, principal therapeutic approach is still medical agents, but surgery and/or radiotherapy must be considered when necessary. Of medical agents, bromocriptine is the most commonly used agent but there has been gradually appeared newer agents, such as cabergoline and quinagolide, with less side effects and long-acting, in this field.Keywords: Hyperprolactinemia, diagnosis, treatmentTurkiye Klinikleri J Med Sci 1999, 19:63-72
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