ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Carnitine: Synthesis, Metabolism, Function Andtherapeutic Importance In The Ischemic Heart
Gönen DENİZ*
* Doç.Dr.,Gülhane Askeri Tıp Akademisi ve Askeri Tıp Fakültesi Tıbbi Farmakoloji AD, ANKARA
Carnitine is a naturally occuring compound in the body, found in high concentration in myocardium and muscular tissue.
In humans it is synthesized from Trimethyllysine in liver, brain and kidney. Muscles takes up carnitine from in the transport of long-chain fatty acids from the cytoplasm to the intramitochondrion, where b-oxidation takes place.
The normal myocardium obtains most of its energy from the oxidation of fatty acids, but this process declines sharply in myocardial ischemia. This inhibition of the energy metabolism of fatty acids is based on inhibition of the intramitochondrial b-oxidation. Ischemia of the heart is accompanied by the tissue accumulation of long-chain fatty acids.
Carnitine is a crucial factor for energy production in the ischemic muscle. Biochemical and physiological studies suggest that the administration of carnitine may benefit the ichemic heart. Although a series questions remain unanswered in this field, they serve as strong stimulants for further researches.Keywords: Carnitine, biosynthesis, deficiency,
Myocardial energy metabolism,
Ischemic heartTurkiye Klinikleri J Med Sci 1999, 19:55-62
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