ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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B7 Molecules And Autoimmun Diseases
Yavuz BAYKAL*, B.Ali ÖZUSLU**, Vedat ERTEN***
* Doç.Dr.,GATA İç Hastalıkları AD,
** Yrd.Doç.Dr.,GATA Kalp-Damar Cerrahisi AD,
*** Dr.,GATA İç Hastalıkları AD, ANKARA
Role of B7-CD28 costimulatory pathway in pathogenesis of chronic diseases is characterized by disturbances during the immun response. Signaling of TH type I cell is the main mechanism in the pathogenesis of autoimmune and granulomatous disease. In those cases, B7 molecules can induce the producing of TH cells as pathology continue. Although up-regulation of B7 in inflammmatory tissues is a seconder proccess. The ratio of type I / type II TH cells causes the anergy by disturbing the cellular immunity. However, what causes both expression of B7 and increasing expression of CTLA-4 receptor or total decreasing of costimulation by the decreasing CD28 molecules, are under investigation.Keywords: Autoimmun disease,
B7 moleculesTurkiye Klinikleri J Med Sci 1999, 19:48-54
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