ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Leptin
Ahmet ERGÜN*
*Doç.Dr.,Ankara Üniversitesi Tıp Fakültesi Fizyoloji AD, ANKARA
Leptin was identified in 1994 and described as an adipocyte derived signalling factor. After interaction with its receptors, it controls body weight, food intake and energy expenditure. Leptin is produced by ob-gen by encoding to mRNA in the adipocyte. Recently it has been shown that leptin to be also produced in non-adipose tissue. Leptin is carried by blood and enters the brain and arrives hypothalamus by a transport system. The capacity of leptin transport sistem is lower in obese individuals and may provide a mechanism for leptin resistance in humans.Leptin circulates in proportion to the amount of adipose tissue in the body. Leptin production is not only determined by fat mass but is also influenced by gender, metabolic hormones, pharmacological agents and current body energy requirements. Nowadays leptin has been inconparated into the therapy of obesity.Keywords: Leptin, obesityTurkiye Klinikleri J Med Sci 1999, 19:130-136
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