ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
|
|
|
Oxidative Stress In Smokers And Copd
Kürşat Uzun*
*Dept. of Chest Diseases and Tuberculosis, Medical School of Yüzüncü Yıl University, Van, TURKEY
There are numerous reports of increased oxidative stress in smokers and in patients with COPD. Cigarette smoke contains abundant amounts of oxygen-based free radicals. In addition, many studies suggest that phagocytes in smokers release increased amounts of reactive oxygen species under certain conditions. The levels of lipid peroxidation products are increased in plasma of patients with acute exacerbations of COPD compared to healthy subjects. There is limited information on the lung antioxidant defences in smokers and COPD. Studies have shown that some antioxidants are decreased in COPD. Thus, in general, it appears that an imbalance between oxidants and antioxidants occurs in cigarette smokers that favours an excess oxidant stress and may play an important role in the pathogenesis of COPD.Keywords: Oxidative stress, smokers, COPDTurkiye Klinikleri J Med Sci 1999, 19:123-129
|
|
|
|
|
