ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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The Place Of Angiogenesis Inhibitors In Cancer Therapy
A. Selmin ATAERGİN*, Ahmet ÖZET**, Fikret ARPACI**
* Dr.,GATA İç Hastalıkları BD,
** Doç.Dr.,GATA Tıbbi Onkoloji BD, ANKARA
Angiogenesis, that is, the formation of new vessels from existing microvessels, is important in embryogenesis, wound healing, therefore in many diseases such of diabetic retinopathy, hemangiomas, psoriasis, arthritis, furthermore in tumor growth. Hypoxia and some other stimuli not well defined, drive tumor, inflammatory, and connective tissue cells to generate angiogenic molecules such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF), transforming growth factor-beta (TGF-beta), platelet-derived growth factor (PDGF), and others.
The ability to mount an angiogenic response is probably present in all tissues. The overall lack of angiogenesis in normal situations probably results from the interaction of a complex series of multifactorial systems, each of which maintained in a state of balance between stimulation and inhibition. An imbalance of any of these systems, may lead to angiogenesis. Pathological angiogenesis is an important factor in many diseases including cancer. Several drugs some in preclinical trials and some in clinical use in cancer therapy, have recently been found to be angiogenesis inhibitors, and this may be their primary mechanism of action.Keywords: Angiogenesis, Cancer,
Angiogenesis inhibitorsTurkiye Klinikleri J Med Sci 1999, 19:100-105
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