ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
|
|
|
|
ORIGINAL RESEARCH ARTICLES |
Morphological Changes On Rat Liver And Serum Chemical Changes During Intensive Muscular Exercise And The Effect Of Carnitine
Ömer COŞKUN*, Recep KUTLUBAY**, Birkan YAKAN**
* Öğr.Gör.Dr.,Erciyes Üniversitesi Tıp Fakültesi Histoloji-Embriyoloji AD,
** Doç.Dr.,Erciyes Üniversitesi Tıp Fakültesi Histoloji-Embriyoloji AD, KAYSERİ
This study was carried out on 80 male adult rats to investigate the morphologic effects of L-Carnitine on liver tissue during intensive muscular exercise. The rats used in this study were divided into 4 equal groups called control, carnitine, exercise and carnitine+exercise groups.
3 ml of 0.9% NaCl were applied to both exercise and control groups. Same volume 0.9% NaCl with 300 mg/kg L-Carnitine were applied to carnitine and carnitine+exercise groups for ten days. Exercise groups were forced to swimming for 30 minutes following the injections.
Liver tissues were prepared, stained and examined using a light microscope. We did not observe any significant difference among the groups when the sections were stained with Haematoxylen-Eosin method. When Best Carmin staining were applied to the sections, considerable glycogen granules were observed in other groups but not in exercise groups. Statistical evaluation supports this result (p<0.01).
We have taken serum samples. Free carnitine levels were significantly low in exercise groups and in other groups it was within normal region.
In the literature body glycogen reservoirs is preserved with treated L-Carnitine in intensive muscular exercise. In our study we observed that intensive muscular exercise decreased free carnitine levels in serum and decrease liver glycogen, reservoirs is preserved by L-Carnitine treatment.Keywords: L-Carnitine, Liver, RatTurkiye Klinikleri J Med Sci 1999, 19:209-214
|
|
|
|
|
