ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Effects Of Dopamine On Lymphocyte Responses Andserum Prolactin Levels In Critically Ill Patients
Cevdet TOKAT*, Yücel ARITAŞ**, Türkân PATIROĞLU***, Ahmet TUTUŞ****,Ömer ŞAKRAK*****, Özhan İNCE******
* Uzm.Dr., Erciyes Üniversitesi Tıp Fakültesi Genel Cerrahi AD,** Prof.Dr., Erciyes Üniversitesi Tıp Fakültesi Genel Cerrahi AD,*** Prof.Dr., Erciyes Üniversitesi Tıp Fakültesi İmmünoloji BD,**** Doç.Dr., Erciyes Üniversitesi Tıp Fakültesi Nükleer Tıp AD,***** Doç.Dr., Erciyes Üniversitesi Tıp Fakültesi Genel Cerrahi AD,****** Arş.Gör., Dr. Erciyes Üniversitesi Tıp Fakültesi Genel Cerrahi AD, KAYSERİ
Dopamine is currently used in the Intensive Care Units (ICU) for its vasopressor, renal vasodilating and cardiac inotropic properties. The relationships between exogenous dopamine and patient hormonal and lymphocyte responses have not been deeply evaluated in the critically ill patient. All patients admitted to our ICU were evaluated for admission into the protocol, excluding patients whose medications or diseases produced effects the study - dependent variables. In this prospective and randomized study critically ill adult patients were divided into two groups. In the study group patients, before institution of dopamine therapy, blood samples were taken for total lymphocyte, T and B cell counts and prolactin measurements. Second blood samples were taken if the dopamine infusion was >5mcg/kg/min for at least 4 hours during that 24-hour period. In the second group, control blood samples for determination of total lymphocyte, T and B cells and prolactin responses were also drawn from ICU patients who did not receive dopamine infusion. An immediate decrease was found in T-cell, B-cell and total lymphocyte counts in dopamine group (p<0.01). Serum prolactin concentrations decreased all patients receiving dopamine infusions at study dose limit (p<0.01). The data suggest the possibility of altered endocrine and immune function as a corollary of therapeutic concentrations of dopamine in critically ill patients.Keywords: Critical illness, Dopamine,
Cellular immune response, ProlactinTurkiye Klinikleri J Med Sci 1999, 19:275-280
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