ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
The Effect Of Prenatal Use Of Ethanol, Bromide Andclomiphene To Fetus Bladder On Rats
Emin BALKAN*, Semiha NOYAN**, Şahin SIRMALI***,Hasan DOĞRUYOL****
* Yrd.Doç.Dr.,Uludağ Üniversitesi Tıp Fakültesi Çocuk Cerrahisi AD,
** Yrd.Doç.Dr.,Uludağ Üniversitesi Tıp Fakültesi Histoloji ve Embriyoloji AD,
*** Prof.Dr.,Uludağ Üniversitesi Tıp Fakültesi Histoloji ve Embriyoloji AD,
**** Prof.Dr.,Uludağ Üniversitesi Tıp Fakültesi Çocuk Cerrahisi AD, BURSA
In our study, we aimed to investigate whether ethanol, bromide and clomiphene having teratogenic effect causes histopathologic changes similar to megacystis microcolon intestinal hypoperistalsis syndrome(MMIHS) on fetus bladder wall when given to pregnant rats.
Fourteen rats were used in control group and 30 rats from each of the other three study groups were used in our study. 2 cc 30% ethanol orogastrically, intraperitoneal 8 mg/kg bromide and 2 mg/kg clomiphene were administrated once a day to study groups from 6th to 12th day of pregnancy. No drug was administrated to control group. Rats were sacrificied on the 20th day of pregnancy. In the histopathologic evaluation of bladder removed from fetuses; organ diameter, wall thickness, vacuolar degeneration in muscles, connective tissue proliferation among muscles, and thickness of tunica muscularis were evaluated. In our experiments, we found that clomiphene is the most affecting substance on bladder. An increase in vacuolar degeneration on muscles was determined in the three groups.
According to the results obtained, similarity to MMIHS findings was determined. It is impossible to prove the hypothesis that the pathology we obtained is MMIHS. But it is possible to say that bladder is affected by prenatal ethanol, bromide and clomiphene intake.Keywords: Megacystis microcolon intestinal
hypoperistalsis syndrome, ethanol,
bromide, clomiphene, bladderTurkiye Klinikleri J Med Sci 1999, 19:259-265
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