ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Lactate And Fatigue
Şeref ERDOĞAN*, S.Sadi KURDAK*
* Dr., Çukurova University, School of Medicine, Department of Physiology, Adana, TURKEY
Muscle fatigue may be defined as a decreased power output in terms of force production and speed and discussed in central and peripheral origin. Peripheral fatigue is caused by an impairment of force generation by the muscle. During intensive muscle contraction, as a result of anaerobic glycolysis, H+ and lactate accumulates in the muscle cell and they may negatively effect the force output. For many years fatigue-inducing action of lactate was discussed together with pH. But in 1995, Hogan et al. showed pH independent fatigue-inducing effect of lactate ion on skeletal muscle and changed this idea. Following to this report, investigators were concentrated on the mechanism of lactate's direct effect (pH independent) on tension development. This review is focused on to distinguish lactate ion and lactic acid induced fatigue from each other.Keywords: Lactate, Lactic acid, FatigueTurkiye Klinikleri J Med Sci 1999, 17:366-369
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