ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Il 12 And Its Role In Treatment Of Cancer
Yavuz BAYKAL*, Gülsüm ÖZET**, Fikri KOCABALKAN***
* Doç.Dr., GATA İç Hastalıkları AD,
** Dr., Ankara Numune Hastanesi,
*** Prof.Dr., GATA İç Hastalıkları AD, ANKARA
Interleukin 12 (IL-12) is a heterodimeric cytokine that has potent effects on innate and adaptive immunity. IL-12 induces interferon gama secretion by T cell and natural killer cells, enhances the proliferation of activated T cell and natural killer cells, augments the cytolytic activity of cytotoxic T lymphocytes and natural killer cells, and support the differentiation of Th 1 effector cells. IL-12 stimulates in vitro antitumor activity of lymphocytes from patients with cancer and in vivo antitumor activity in many murine tumor models.
Current data indicate that CD4 cells, CD8 T cells, natural killer cells and interferon gamma may contribute to the antitumor effects of IL-12 therapy. However, further investigation is required to elucidate the precise mechanisms involved in the antitumor activity of IL-12.Keywords: Interleukin 12, CancerTurkiye Klinikleri J Med Sci 1999, 19:344-351
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