ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Effects Of Dietary Supplementation Of Catechin On Antioxidantenzyme Activities And Lipid Peroxidation Levels In Rats
Abdurrahim KOÇYİĞİT*, S. Oktay ARSLAN**, Özcan EREL*,Necmettin AKTEPE***, Şenel AVCI****, Selahaddin GÜR*****
* Yrd.Doç.Dr., Harran Üniversitesi Tıp Fakültesi Biyokimya ve Klinik Biyokimya AD,** Yrd.Doç.Dr., Harran Üniversitesi Tıp Fakültesi Farmakoloji AD,*** Bil.Uz., Harran Üniversitesi Tıp Fakültesi Biyokimya ve Klinik Biyokimya AD,**** Dr., Harran Üniversitesi Tıp Fakültesi Biyokimya ve Klinik Biyokimya AD,***** Biyolog, Harran Üniversitesi Tıp Fakültesi Biyokimya ve Klinik Biyokimya AD, ŞANLIURFA
The purpose of this investigation was to study the effect of dietary consumption of the catechin on erythrocyte antioxidant enzyme activities and lipid peroxidation (Lpx) in rats. The first group of rats was fed a commercial basal diet as control group. Second group was given the same basal diet supplemented with 1% catechin for three weeks. Erythrocyte superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and Lpx levels were measured by spectrophotometric methods. Erythrocyte SOD and GSH-Px activities were significantly higher (p<0.05, p<0.01 respectively) and, Lpx levels lower (p<0.01) in catechin supplemented group than those of controls. There was a strong negative relationship between GSH-Px and Lpx levels (r=-0.881 p<0.01) and a relatively weak negative relationship between SOD and Lpx levels (r=0.635 p<0.05) in catechin group. The results suggest that dietary supplementation of catechin causes a decrease in erythrocyte Lpx level and this effect may be originated from induction of antioxidant enzymes.Keywords: Catechin, Glutathione peroxidase,
Lipid peroxidation, Superoxide dismutaseTurkiye Klinikleri J Med Sci 2000, 20:1-4
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