ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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Heat Shock Proteins And Their Role In Diseases
Yavuz BAYKAL*, Faysal GÖK**, Fikri KOCABALKAN***
* Doç.Dr., GATA İç Hastalıkları BD,
** Dr., GATA İç Hastalıkları BD,
*** Prof.Dr., GATA İç Hastalıkları BD, ANKARA
Heat shock proteins (HSPs) are family of proteins with diverse functions, whose common features that they are produced when a cell is exposed to environmental insults such as a sudden change in temperature, anoxia, reactive oxygen metabolites or altered glucose levels. Heat shock proteins are a group of proteins produced by cells of all species in response to a variety of stressful stimuli. They are highly conserved between prokaryotes and eukaryotes and consequently the host immune response, initially directed against bacterial HSPs could become redirected against its own HSPs. Human synovial T cells frequently recognize Mycobacterium tuberculosis 65kDa HSPs, and antibodies against this antigen are frequently elevated in the blood.Keywords: Heat shock proteinsTurkiye Klinikleri J Med Sci 2000, 20:187-195
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