ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Can The Results Of Skin Testing Be Read Accordingto Individual Variation?
Kamuran KONCA*, Cengiz PATA*, Esen AKBAY*, Aziz YAZAR*
*Yrd.Doç.Dr., Mersin Üniversitesi Tıp Fakültesi İç Hastalıkları AD, MERSİN
Purpose: The standardized criteria accepted in the assessment of skin tests that are used in the evaluation of IgE-mediated type I immunologic reactions do not take into account the effects of individual variation. In this study, we investigated whether skin testing can be assessed according to individual variation.
Method: Standard epidermal puncture and intradermal test procedure were performed in decathlicate among a group of 30 healthy individuals (15 men, 15 women) with statistical evaluation of the results. In the second part, it is evaluated whether the intradermal test results of individuals who sensitized or not sensitized with vespid antigens were in accordance with the results of the first part.
Results: The variation rate of skin testing was investigated among a group of 30 healthy individuals by using negative and positive controls in decathlicate and found that wheal reactions had a lower rate of variation than flares. The values of variation coefficient between 95% and 99.9% confidence limits seem to be a reasonable cutoff which may slightly differ according to the equipment used in skin testing. The results of intradermal tests, done by using vespid antigens, of 17 individuals who had never exposed and 19 individuals who had exposed to vespid venom in the recent 5 years support the definition of this cut off value.
Conclusion: The values between the 95%-99.9% confidence limits of mean variation coefficient are appropriate cut off values. Increasing the precision of measurement and the number of negative control tests would serve to refine the cut off found and insure the reliability of tests in clinical application.Keywords: Skin testingTurkiye Klinikleri J Med Sci 2000, 20:160-166
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