ISSN: 1300-0292
İndekslendiği Dizinler: SCIENCE CITATION INDEX EXPANDED
CINAHL, Index Copernicus,
Chemical Abstracts (CA),
Excerpta Medica / EMBASE
Dil: Türkçe, İngilizce
İçerik: Orijinal Araştırma, Derleme, Editöre Mektup, Olgu Sunumu, Tıp Eğitimi, Tıbbi Kitap İncelemeleri
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ORIGINAL RESEARCH ARTICLES |
Adverse Effects Due To Daily Interferon Alpha In Patients With Chronic Viral Hepatitis
H. Cem GÜL*, Can P. EYİGÜN**, Ömer COŞKUN***, Efraim ADAM*,
A. Bülent BEŞİRBELLİOĞLU**, Volkan ÖZGÜVEN**
* Uz.Dr., GATA Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji AD,
** Doç.Dr., GATA Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji AD,
*** Asist.Dr., GATA Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji AD, ANKARA
A total of 88 patients (Mean age: 28.5 ± 5.69 years and range: 21 to 47) in recent study were treated with a dose of 5 Million Unit interferon-a (IFN-a) daily for 6 months. Of 88 patients , seventy one had chronic hepatitis B and 17 chronic hepatitis C. Of 88 patients, sixty six were male and 22 female.
In our study, the most often observed adverse effect was fever (95%; 84/88). The mean body temperature was 40° ± 1.04°C for the first day of treatment and 38.2° ± 2.03°C, 37.1° ± 1.7°C, 36.7° ± 1.5°C during treatment period for the following three days respectively. For the rest of days, during the treatment period, the mean body temperature was in normal ranges.
The second adverse effect was weight loss (90%; 80/88). Mean weight loss was 5.5 ± 2.04 kg during the treatment period. The third was headache (78%; 70/88) lasting 2 ± 1.3 days.
Other adverse effects observed were chills in 65 per cent (57/88), myalgia in 60 per cent (53/88), concentration disorder in 40 per cent (35/88), nausea in 25 per cent (22/88), sleep disorder in 20 per cent (18/88), erythema of injection site in 19 per cent (17/88), alopecia in 13 per cent (11/88), arrhythmia in 2 per cent (2/88), vomiting in 2 per cent (2/88). Impotence was observed in 58 per cent (38/66) male patients.
The treatment was stopped in two patients in the forth and fifth months of the treatment because of their suicidal ideas. One patient was treated with an antidepressant drug for developing depression. Antihypothyroid drugs were begun for two patients because of hypothyroidism. Additionally, anti-infective therapy was given to 1 (1%) patient for pneumonia, to 1 (1%) patient for bronchitis and to 1 (1%) patient for urinary tract infection.
In conclusion, no serious adverse effect was observed during daily IFN-a therapy used for chronic viral hepatitis.Keywords: Daily IFN-a, Chronic viral hepatitis,
Adverse effectTurkiye Klinikleri J Med Sci 2000, 20:221-225
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